Allelotyping for loss of heterozygosity on chromosome 18 in gastric cancer

• 作 者: Jing-CuiYu Kai-LaiSun BuoLiu S
• 机 构: DepartmentofMedicalGenetics,DepartmentofMedicalGenetics,ChineseNationalHumanGenomeCenter,Laboratoryo
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2004年13期
• 关键词: 等位基因型 杂合性 丢失基因 染色体18 胃癌 肿瘤 PCR 多态性
• 基金项目: Supported by the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions by Ministry of Education of China and the National Natural Science Foundation,No.30

AIM: To investigate the association between loss of heterozygosity (LOH) on chromosome 18 and sporadic gastric cancer.METHODS: Multiplex PCR was used to screen 14 highly polymorphic microsatellite markers on chromosome 18 in 45 cases of primary gastric ca