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肠道菌群与机体健康密切相关,而遗传和环境因素均可导致菌群结构紊乱。肠黏膜固有免疫作为非特异性免疫的一部分主要参与肠道屏障功能的维护。近年来有报道指出肠道菌群与黏膜固有免疫相互作用和影响,并与肠道菌群结构长期相对稳定密切相关。2010年,“Nature”和“Science”较早发表用高通量测序技术研究肠道菌群的报道[1-2],此后,肠道菌群被称为人类第二基因组,不仅与肠功能障碍和代谢相关,亦与肿瘤甚至精神
Intestinal flora and health are closely related to the body, and genetic and environmental factors can lead to structural disorders flora. Intestinal mucosal innate immunity is primarily involved in the maintenance of intestinal barrier function as part of nonspecific immunity. In recent years, it has been reported that intestinal microflora and mucosal innate immune interactions and effects, and intestinal flora structure is relatively stable and long-term are closely related. In 2010, “Nature” and “Science” earlier published reports on the study of intestinal microflora by high-throughput sequencing [1-2]. Since then, the intestinal microflora has been referred to as the human second genome, Not only with intestinal dysfunction and metabolism, but also with the tumor or even mental