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目的探讨中性红(neutral red,NR)测定人体胃粘膜血流(GMBF)的可行性及临床意义。方法正常组11名先静注负荷量 NR(300或400μg/kg),然后按上述剂量恒速静点。1h 后肌注五肽胃泌素(6μg/kg),同步定时收集胃液和采血至2h 结束后测定 NR 浓度并进行各项计算。12例慢性浅表胃炎(CSG 组)及13例十二指肠溃疡病(DU 组)以 NR 300μg/kg给药,用同法测定1h 结束。结果正常组不同时间、不同剂量下NR 的 G/B 比率基本稳定(P>0.05),GMBF 与泌酸量和胃液分泌量的 r 分别为0.84和0.87。CSG 组各测定值接近正常组。DU 组 GMBF 下降明显(P<0.01),基础泌酸量与正常组和 CSG组的差异无显著性(P>0.05)。结论 NR 清除法测定人体 GMBF 稳定可靠,重复性好。正常组和 CSG 组的GMBF 与泌酸量、胃液分泌量呈正相关,而 DU 组的 GMBF 与泌酸量的相关性发生改变。
Objective To investigate the feasibility and clinical significance of neutral red (NR) determination of human gastric mucosal blood flow (GMBF). Methods The normal group of 11 first intravenous injection of load NR (300 or 400μg / kg), and then the above dose constant speed static point. Five hours later, pentagastrin (6μg / kg) was intramuscularly injected. The gastric juice was collected simultaneously and the blood was taken until the end of 2h. The concentration of NR was measured and calculated. 12 cases of chronic superficial gastritis (CSG group) and 13 cases of duodenal ulcer disease (DU group) were given NR 300μg / kg, with the same method as the end of 1h. Results The G / B ratio of NR in the normal group was basically stable at different times (P> 0.05). The rms of GMBF, acid secretion and gastric secretion were 0.84 and 0.87, respectively. The measured value of CSG group is close to normal group. The GMBF in DU group decreased significantly (P <0.01), while the basal oxytocin level had no significant difference between normal group and CSG group (P> 0.05). Conclusion NR clearance method for the determination of human GMBF stable and reliable, good repeatability. GMBF in normal group and CSG group was positively correlated with acid secretion and gastric juice secretion, while the correlation between GMBF and acid secretion in DU group was changed.