论文部分内容阅读
糖精是作过全面试验的一种添加剂。有人曾用大鼠、小鼠和地鼠作过十几次一代动物致癌试验,未发现过致癌作用。另有人在二次两代动物致癌试验中,发现雄性大鼠膀胱肿瘤发生率增高,所用动物是在断乳后喂以母鼠饲料,其中含糖精5或7.5%。对试验所用糖精的化学分析表明,其中主要不纯物是邻甲苯磺酰胺(ortho-toluene-sulfonamide,简称OTS),浓度为118～6,100 ppm。O-TS在化学结构上很象另一种磺酰胺,即4-乙磺酰基-萘-
Saccharin is an additive that has been thoroughly tested. Some people used rat, mouse and hamster do a dozen times animal carcinogenic test, found no carcinogenic effect. Others in the second two generations of animal carcinogenesis test found that the incidence of bladder tumors in male rats increased, the animals used after weaning fed female rats feed, which contains saccharin 5 or 7.5%. The chemical analysis of the saccharin used in the experiment showed that the major impurity was ortho-toluene-sulfonamide (OTS) at a concentration of 118-6,100 ppm. O-TS is chemically similar to another sulfonamide, 4-ethanesulfonyl-naphthalene-