论文部分内容阅读
对非特殊性急性肾衰竭(不包括由肾小球肾炎,肾血管疾病及间质性肾炎等特异性原因引起的急性肾衰竭)虽然进行了几十年的研究,但是对其病理生理学还不十分清楚。目前,有两种主要的看法:一种强调肾小管坏死是肾衰竭的主要原因,另一种强调血管收缩是其主要原因。这篇综述采用了动物和人体观察所得到的资料,对这些发病原理进行了分析。动物模型可作直接显微穿刺术,以得到广泛的资料,病人的研究资料虽然是片断和间接的,但仍值得注意,因为动物模型特别是肾缺血后型与人的急性肾衰竭并不一致。
Although decades of research has been conducted on nonspecific acute renal failure (excluding acute renal failure caused by specific causes such as glomerulonephritis, renal vascular disease and interstitial nephritis), the pathophysiology of non-specific acute renal failure Very clear. At present, there are two main views: one emphasizes that renal tubular necrosis is the main cause of renal failure, and the other is the main reason that vasoconstriction is emphasized. This review uses data from animal and human observations and analyzes the pathogenesis. The animal model can be used for direct microscopic aspiration to obtain a wide range of data, although the patient’s information is fragmentary and indirect, but it is still worth noting because animal models, especially those with postrenal ischemia, are not consistent with acute renal failure in humans .