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山石榴Randia dumentorum(Retz)Lam,是广泛分布在印度的一种灌木,果实为众所周知的民间药,有抗痉挛,抗痢疾和抗生育的特性,也用作毒鱼剂和清洁剂。曾报道分离了几种皂甙及其部分结构。在对药用植物进行生物筛选,寻找有活性的皂甙时,发现山石榴果实的甲醇提取物具有增强免疫,溶血和灭螺活性,促使作者对该药物进一步研究。虽然现已阐明果实中的三种三萜类皂甙结构,但是TLC分析显示有更多的皂甙存在。本文报道了山石榴果实中的另外两种新的三萜类皂甙和五种已知皂甙的鉴定及其生物活性。
Pomegranate Randia dumentorum (Retz) Lam is a shrub widely distributed in India. Its fruit is a well-known folk medicine. It has anti-spawning, anti-dysentery and anti-fertility properties. It is also used as poisoning agent and cleaning agent. It has been reported that several saponins and their partial structures have been isolated. In the bioscreening of medicinal plants and the search for active saponins, it was found that the methanol extract of Pomegranate Fruit has enhanced immunity, hemolysis, and molluscicidal activity, prompting the authors to further study the drug. Although three triterpenoid saponin structures have been elucidated in fruits, TLC analysis showed more saponins. This paper reports the identification and bioactivity of two other new triterpenoid saponins and five known saponins in the fruit of Pomegranate.