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目的:分析天水市秦州区出生缺陷的变化趋势,为降低出生缺陷发生率采取有效的干预措施提供科学依据。方法:对2004~2007年天水市6家监测点医院住院分娩的13 683例围产儿(包括活产、死胎、死产、治疗性引产)进行监测,分析出生缺陷情况。结果:出生缺陷平均发生率为78.93万/,前5位出生缺陷是神经管畸形、总唇腭裂、四肢指(趾)畸形、耳畸形、直肠肛门闭锁(脐膨出、腹裂并列)。结论:2004~2007年秦州区出生缺陷发生率有逐年上升趋势;总唇腭裂和四肢畸形城镇发生率明显高于农村,神经管畸形发生率农村明显高于城镇;神经管畸形所占比例超过出生缺陷的一半,预防神经管畸形的工作重点应放在农村;颜面部畸形和四肢畸形的预防不能忽视城镇。
OBJECTIVE: To analyze the trend of birth defects in Qinzhou District of Tianshui City and provide scientific basis for effective intervention measures to reduce the incidence of birth defects. Methods: A total of 13 683 perinatal infants (including live births, stillbirths, stillbirths and therapeutic abortion) were hospitalized in 6 hospitals in Tianshui City from 2004 to 2007 to analyze the birth defects. Results: The average incidence of birth defects was 789,300 /. The first five birth defects were neural tube defects, total cleft lip and palate, phalanges of the limbs, ear deformities and anorectal atresia (umbilical swelling and abscesses). Conclusion: The incidence of birth defects in Qinzhou District increased year by year from 2004 to 2007. The incidence of cleft lip and palate and limb deformities was significantly higher in rural areas than in rural areas. The incidence of neural tube defects was significantly higher in rural areas than in urban areas. The proportion of neural tube defects exceeded Half of birth defects, prevention of neural tube defects should focus on rural work; face facial deformities and limb deformities prevention can not be ignored in cities and towns.