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目的探讨真实世界中疏血通注射液临床用药特征,为合理安全用药提供参考。方法利用全国18家三甲医院信息系统数据,采用频数分析法描述使用疏血通患者的年龄、性别、职业、适应症。利用Apriori算法、Clementine12.0软件建立疏血通与其他药物合并使用的相关模型,得出疏血通常用的合并用药种类。结果疏血通的目标人群多为中老年人,男性多于女性;常用剂量范围是2~6 m L,常用溶媒是0.9%氯化钠注射液,常用给药途径是静脉注射;临床上多用于心脑血管疾病;与抗凝及血管扩张类药物联合使用居多,如阿司匹林、肝素、硝酸异山梨酯、氢氯吡格雷等。结论疏血通注射液的使用方法多遵循药品说明书,但在使用剂量、溶媒等,特别是合并用药方面仍需根据患者实际情况谨慎处理,预防不良反应的发生。
Objective To explore the clinical characteristics of Shuxuetong injection in the real world and provide a reference for reasonable and safe medication. Methods The information system data of 18 top three hospitals in China were used to describe the age, sex, occupation and indications of patients using Shuhexintong using frequency analysis. Using Apriori algorithm, Clementine12.0 software to establish the relevant model of Shuxuetong used in combination with other drugs to get the commonly used types of drug combination. Results Shuxuetong the target population mostly middle-aged and older, more men than women; commonly used dose range is 2 ~ 6 m L, 0.9% sodium chloride injection is commonly used vehicle, the usual route of administration is intravenous injection; clinical use In cardiovascular disease; and anticoagulant and vasodilators drugs most commonly used, such as aspirin, heparin, isosorbide dinitrate, such as clopidogrel. Conclusion The use of Shuxuetong injection more follow the instructions of the drug, but in the use of dose, solvent, etc., especially in combination with medication still need to be cautious according to the actual situation of patients to prevent the occurrence of adverse reactions.