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研究低硒与Ｔ－２毒素对脂质过氧化物代谢的复合作用。实验采用析因设计。对象为断奶ＳＤ大鼠，随机分为４组：Ⅰ．低硒组；Ⅱ．低硒＋Ｔ－２毒素组；Ⅲ．补硒组；Ⅳ补硒＋Ｔ－２毒素组。各组动物均饲以硒含量为０．００９±０．００１μｇ／ｇ的低硒饲料，Ⅲ、Ⅳ两组饲料中加入０．２μｇ／ｇ的亚硒酸钠，Ⅱ、Ⅳ两组动物经口灌服Ｔ－２毒素，剂量为０．２６６６ｍｇ／ｋｇ·ｄ。进入实验３０天后活杀，测定全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力、血清及肝脏丙二醛（ＭＤＡ）含量。结果显示低硒与Ｔ－２毒素均对大鼠全血ＧＳＨ－Ｐｘ活力、肝脏ＭＤＡ含量有显著影响（Ｐ＜０．０５），但两者之间交互作用不显著（Ｐ＞０．０５）；对血清ＭＤＡ含量无明显作用（Ｐ＞０．０５）。
To study the combined effects of low selenium and T-2 toxin on lipid peroxidation. Experiment using factorial design. Subjects were weaned SD rats were randomly divided into four groups: Ⅰ. Low selenium group; Ⅱ. Low selenium + T-2 toxin group; Ⅲ. Selenium group; Ⅳ selenium + T-2 toxin group. The animals in each group were fed with low-selenium diet with a selenium content of 0.009 ± 0.001 μg / g, and 0.2 μg / g sodium selenite was added to the groups Ⅲ and Ⅳ. T-2 toxins fed a dose of 0.2666mg / kg · d. Thirty days after the experiment, the cells were sacrificed and the activity of glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum and liver were measured. The results showed that low selenium and T-2 toxin all had significant effects on GSH-Px activity and liver MDA content in whole blood (P <0.05), but there was no significant interaction between them (P> 0.05) ; No significant effect on serum MDA content (P> 0.05).