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目的探讨阿司匹林联合氯吡格雷治疗短暂性脑缺血发作的疗效及对血清C反应蛋白(CRP)与神经功能恢复的影响。方法选取我院69例短暂性脑缺血发作患者,随机分组,对照组34例,观察组35例,对照组给予阿司匹林治疗,观察组予以氯吡格雷联合阿司匹林治疗,观察比较两组治疗效果及血清CRP水平、神经功能缺损评分。结果观察组治疗总有效率为82.86%,高于对照组61.76%,差异具有统计学意义(P<0.05);观察组血清CRP水平及神经功能缺损评分均低于对照组,差异具有统计学意义(P<0.05)。结论氯吡格雷、阿司匹林联合治疗短暂性脑缺血发作疗效显著,可有效改善患者血清C反应蛋白水平及神经功能。
Objective To investigate the effects of aspirin combined with clopidogrel in the treatment of transient ischemic attack and its effect on serum C-reactive protein (CRP) and neurological function. Methods Sixty-nine patients with transient ischemic attack were randomly divided into control group (n = 34), observation group (n = 35), aspirin control group and clopidogrel plus aspirin group Serum CRP level, neurological deficit score. Results The total effective rate of the observation group was 82.86%, which was higher than that of the control group (61.76%), the difference was statistically significant (P <0.05). The serum CRP level and neurological deficit scores of the observation group were lower than those of the control group (P <0.05). Conclusion The combination therapy of clopidogrel and aspirin has significant effect on transient ischemic attack, which can effectively improve the level of serum C-reactive protein and neurological function.