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目的 探讨脑卒中与胰岛素抵抗之间的关系。 方法 以空腹血糖和空腹胰岛素乘积的倒数作为胰岛素敏感性指数 ,对 78例急性脑卒中患者和 30例对照者进行研究 ,并分别测定血脂代谢情况。 结果 脑卒中患者无论是否合并高血压均存在胰岛素抵抗和高胰岛素血症 (P <0 .0 1 )。胰岛素敏感性与高密度脂蛋白浓度呈正相关(r=0 .42 ,p <0 .0 1 ) ;与低密度脂蛋白、总胆固醇浓度呈负相关 (r=- 0 .2 8,p <0 .0 5、r=- 0 .51 ,p <0 .0 5)。 结论 急性脑卒中患者存在胰岛素抵抗、高胰岛素血症 ,并与血脂代谢存在密切相关性。
Objective To explore the relationship between stroke and insulin resistance. Methods Using the reciprocal of the product of fasting blood glucose and fasting insulin as the index of insulin sensitivity, 78 patients with acute stroke and 30 controls were studied, and the lipid metabolism was measured respectively. Results There was insulin resistance and hyperinsulinemia in stroke patients with or without hypertension (P <0.01). Insulin sensitivity was positively correlated with high density lipoprotein (r = 0.42, p <0.01), but negatively correlated with low density lipoprotein and total cholesterol (r = - 0.28, p <0 .0 5, r = - 0 .51, p <0. 05). Conclusion There is insulin resistance and hyperinsulinemia in patients with acute stroke, and it is closely related to the lipid metabolism.