论文部分内容阅读
目的通过流行病学调查探讨各年龄、性别在不同类型的燃煤性儿童氟骨症的分布情况和相关血清学指标变化,为儿童氟骨症发病机制研究提供思路。方法以贵州省织金县燃煤型氟中毒重病区为研究现场,对当地6~16岁儿童整群抽样,运用横断面调查研究方法研究不同特征的人群分布,并进行氟斑牙、X线检查和血清学检测。结果织金县燃煤型氟病区儿童氟骨症检出率为7.55%;不同年龄儿童的检出率差异有统计学意义(P<0.05),10~<13岁组和13~16岁组的检出率均高于6~<10岁组(P<0.05)。全血微量元素中钙、镁、铁、锌、铜等含量,氟骨症组和对照组之间差异均有统计学意义(P<0.05);血清磷2组之间差异无统计学意义(P>0.05)。正常儿童和氟骨症儿童血清中骨保护素(OPG)与碱性成纤维细胞生长因子(bFGF)含量的差异均有统计学意义(P<0.05)。氟骨症硬化型与正常对照组之间OPG含量和bFGF含量的差异有统计学意义(P<0.05)。结论氟骨症在织金县燃煤型氟病区儿童人群中的总检出率较高,检出率随年龄增长而增长。氟骨症儿童的全血微量元素由于氟改变骨代谢和细胞毒性的影响下降明显。氟骨症儿童的OPG与bFGF作为骨代谢血清标志物与对照组对比时分别下降和上升,特别是在硬化型的氟骨症少儿童中这种差异更加明显。
Objective To investigate the distribution of skeletal fluorosis and related serological markers in different types of coal-fired children by epidemiological investigation and to provide a way for the study on the pathogenesis of skeletal fluorosis in children. Methods Taking the coal-burning fluorosis area in Zhijin County, Guizhou Province as the research site, the local children aged 6-16 years were sampled in a cluster and the cross-sectional investigation was used to study the population distribution of different characteristics. The dental fluorosis, X-ray Check and serological tests. Results The detection rate of skeletal fluorosis in children with fluorosis in Zhijin County was 7.55%. The detection rate of children with different ages was statistically significant (P <0.05). The detection rate of skeletal fluorosis in children aged 10 ~ <13 years and 13 ~ 16 years The detection rate was higher than that of 6 ~ <10 years old group (P <0.05). The levels of trace elements such as calcium, magnesium, iron, zinc and copper in the whole blood were significantly different between the skeletal fluorosis group and the control group (P <0.05). There was no significant difference between the two groups P> 0.05). The serum levels of osteoprotegerin (OPG) and basic fibroblast growth factor (bFGF) in normal children and children with skeletal fluorosis were significantly different (P <0.05). The difference of OPG content and bFGF content between scleroderma and normal control group was statistically significant (P <0.05). Conclusion The total detection rate of skeletal fluorosis in children population with fluorosis in Zhijin County is high, and the detection rate increases with age. The whole blood trace elements of children with skeletal fluorosis decreased significantly due to changes in bone metabolism and cytotoxicity. Compared with the control group, OPG and bFGF in skeletal muscle of children with skeletal fluorosis decreased and increased respectively when compared with the control group, especially in scleroderma of skeletal fluorosis.