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1959年Prinzmetal描述了一组伴有暂时性ST段抬高,与心肌需氧量增加无明显关系的心绞痛,曾称为Prinzmetal心绞痛。由于在此之前亦有其他作者描述过,因此,1979年国际心脏病学会和WHO对缺血性心脏病的命名及诊断标准中,将这一类心绞痛命名为变异型心绞痛,属于自发性心绞痛范围。自六十年代以来,随着血管造影术、动态心电图、血液动力学监测和同位素标记新技术的应用,对变异型心绞痛的临床表现、病理机制、诊断和治疗都有了进一步的认识,并找到钙拮抗剂等有效药物,从而改善了预后。
In 1959, Prinzmetal described a group of angina pectoris with transient ST-segment elevation and no significant relationship with increased myocardial oxygen demand, which was called Prinzmetal angina pectoris. As previously described by other authors, therefore, in 1979 the International Society of Cardiology and the WHO on the naming and diagnosis of ischemic heart disease standard, this type of angina known as variant angina, a range of spontaneous angina . Since the 1960s, with the application of new techniques of angiography, Holter monitoring, hemodynamic monitoring and isotope labeling, the clinical manifestations, pathological mechanisms, diagnosis and treatment of variant angina have been further recognized and found Calcium antagonists and other effective drugs, thereby improving the prognosis.