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本工作观察了静脉注入放射性碘(~(125)Ⅰ)标记的人胰多肽(HPP)后放射性在小鼠体内的分布,从而探索胰多肽在体内的特异性结合部位。结果发现,在注入~(125)ⅠHPP后3分钟和10分钟,放射性主要在胆囊、肾和肝内有浓集。注入后20分钟,胆囊和肾内的放射性较3分钟时已降低很多;而尿中的放射性却显著增加。以上结果提示,胆囊可能是胰多肽的主要结合部位,肾可能是它的主要排出途径,而肝或者是胰多肽的结合部位,也或者是它的降解部位。
This work observed the intravenous injection of radioactive iodine (~ (125) Ⅰ) labeled human pancreatic polypeptide (HPP) radioactivity distribution in mice in order to explore the pancreatic polypeptide in the body specific binding sites. As a result, it was found that radioactivity mainly concentrated in gall bladder, kidney and liver 3 minutes and 10 minutes after the injection of 125IHPP. 20 minutes after injection, the radioactivity in the gallbladder and the kidneys has been much lower than in 3 minutes; whereas radioactivity in the urine has increased significantly. The above results suggest that the gallbladder may be the main binding site of pancreatic polypeptide, the kidney may be its main route of discharge, and liver or pancreatic polypeptide binding site, or its degradation site.