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用高效液相色谱接电化学检测器(HPLC-ED)测定脑室液儿茶酚胺的含量,对6例施行肾上腺髓质尾状核移植术的PD患者进行了手术前后的动态观察,并设置对照组,发现:①移植术前后多巴胺的含量有明显改变,术后含量增高;②移植术前后去甲基肾上腺素的含量没有显著变化;③与中枢神经系统疾病非PD患者相比较,PD患者术前脑室液中多巴胺含量没有明显降低。研究结果提示:自体肾上腺髓质脑内移植后,能使脑内多巴胺的含量有明显增高。PD患者脑内存有严重的多巴胺利用障碍,移植手术对此可能有改善作用。
The contents of catecholamines in the ventricles were determined by HPLC-ED. Six patients with PD who underwent adrenomedullic caudate nucleus transplantation were observed before and after surgery, and the control group, The results showed that: (1) The content of dopamine in the patients with PD had significant changes before and after the operation, and the postoperative content increased; (2) There was no significant change in the content of norepinephrine before and after transplantation; (3) Compared with non-PD patients with central nervous system diseases, Dopamine content in forebrain ventricular fluid was not significantly reduced. The results suggest that: intracerebral autotransplantation of adrenal medulla, brain dopamine levels were significantly increased. PD patients with severe dopamine disruption in the brain, transplant surgery may improve this effect.