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目的检测CK17、p16、Ki-67和p63在宫颈鳞状上皮不成熟化生(IM)和宫颈上皮内瘤变(CIN)中的表达和意义。方法应用免疫组化SP法检测宫颈IM15例和CIN30例组织标本中的p16、CK17、p63和Ki-67的表达水平,并对其表达和意义进行分析。结果CK17在宫颈IM中的阳性表达率为100%,明显高于LSIL和HSIL组(10%和15%,P<0.01);p16在LSIL和HSIL中的表达率均为100%,明显高于IM组(13.3%,P<0.01);Ki-67的表达在IM和CIN中差异极显著(P<0.01);p63在宫颈IM和LSIL、HSIL中的阳性表达率均为100%,各组间差别不显著(P<0.01)。结论CK17和p16在宫颈IM和CIN病变中表达具有明显差异,有助于两种病变的鉴别诊断。
Objective To detect the expression and significance of CK17, p16, Ki-67 and p63 in cervical squamous epithelial immature metaplasia (IM) and cervical intraepithelial neoplasia (CIN). Methods Immunohistochemical SP method was used to detect the expression of p16, CK17, p63 and Ki-67 in cervical specimens of 15 cases of IMIN and 30 cases of CIN, and its expression and significance were analyzed. Results The positive rate of CK17 in cervical IM was 100%, which was significantly higher than that in LSIL and HSIL (10% and 15%, P <0.01). The positive rate of p16 in LSIL and HSIL was 100% IM and CIN (13.3%, P <0.01). The expression of Ki-67 in IM and CIN was significantly different (P <0.01). The positive rates of p63 in IM, LSIL and HSIL were 100% The difference was not significant (P <0.01). Conclusion CK17 and p16 expression in cervical IM and CIN lesions have significant differences, contribute to the differential diagnosis of two lesions.