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目的：探讨增殖细胞核抗原（ＰＣＮＡ）与胃癌组织的浸润性及转移能力的关系，证明ＰＣＮＡ可作用胃癌预后指标。方法：应用Ｓ－Ｐ免疫组化技术检测了４２例胃癌ＰＣＮＡ的表达。结果：显示ＰＣＮＡ的阳性表达率为９０．０４％（３８／４２）。癌细胞浸润达肌层、浆膜层者ＰＣＮＡ指数显著高于浸润至粘膜下层组（Ｐ＜０．０５）；淋巴结癌转移阳性组ＰＣＮＡ指数显著高于无淋巴结转移组（Ｐ＜０．０１）；胃癌不同分化程度各组中ＰＣＮＡ指数无差异。结论：ＰＣＮＡ对判断胃癌患者的预后是一个有用的指标
Objective: To investigate the relationship between proliferating cell nuclear antigen (PCNA) and invasiveness and metastasis of gastric cancer, and to prove that PCNA can play a role in the prognosis of gastric cancer. Methods: The expression of PCNA in 42 cases of gastric cancer was detected by S-P immunohistochemistry. Results: The positive rate of PCNA expression was 90.04% (38/42). The PCNA index of cancer cells infiltrating into muscle layer and serosal layer was significantly higher than that of infiltration into submucosa group (P<0.05); the PCNA index of lymph node metastasis positive group was significantly higher than that of no lymph node metastasis group (P<0.01). There was no difference in PCNA index between different groups of gastric cancer. Conclusion: PCNA is a useful indicator to determine the prognosis of patients with gastric cancer