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目的:评价含呋喃唑酮或铋剂的四联疗法根除幽门螺杆菌(Hp)的疗效和安全性。方法:收集郑州大学第一附属医院门诊诊断为幽门螺旋杆菌阳性的胃十二指肠溃疡患者288例,随机分为A、B两组。A组(144例):雷贝拉唑10 mg+阿莫西林1000 mg+克拉霉素500 mg+呋喃唑酮100 mg,每天2次,7 d;B组(144例):雷贝拉唑10 mg+枸椽酸铋钾220 mg+阿莫西林1000 mg+克拉霉素500 mg,每天2次,7 d;治疗结束停药4周后空腹行尿素呼气试验,结果阴性者判为根除成功。结果:268例(93.06%)患者完成治疗及随访,20例患者因各种原因未能完成有效随访。A组中共125例根除成功(95.42%),B组根除成功的人数为122人(89.05%),A组的治疗效果优于B组,差异具有统计学意义(P<0.05)。结论:相对于含铋剂而言,含呋喃唑酮的四联疗法根治幽门螺旋杆菌的效果更好。
Objective: To evaluate the efficacy and safety of quadruple therapy with furazolidone or bismuth in the eradication of Helicobacter pylori (Hp). Methods: A total of 288 patients with gastroduodenal ulcer diagnosed as Helicobacter pylori diagnosed by the First Affiliated Hospital of Zhengzhou University were randomly divided into A and B groups. Group A (n = 144): rabeprazole 10 mg + amoxicillin 1000 mg + clarithromycin 500 mg + furazolidone 100 mg twice daily for 7 days; group B (n = 144): rabeprazole 10 mg + citrate Bismuth potassium 220 mg + amoxicillin 1000 mg + clarithromycin 500 mg twice a day for 7 days; after the end of treatment for 4 weeks, the fasting urea breath test was performed, and the result was negative for successful eradication. Results: 268 patients (93.06%) completed treatment and follow-up, 20 patients failed to complete an effective follow-up for various reasons. A group of 125 cases of successful eradication (95.42%), B group of successful eradication of the number of 122 (89.05%), A group of better than the B group, the difference was statistically significant (P <0.05). Conclusion: Compared with bismuth-containing agents, furazolidone-containing quadruple therapy is effective in treating H. pylori.