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目的:了解兰州地区成年女性感染人乳头瘤病毒(humanpapillomavirus,HPV)及其基因类型分布状况,为本地区HPV分子流行病学研究提供理论依据。方法:利用PCR技术分别对100例妇科门诊就诊者进行HPV基因亚型检测。结果:100例样品中,HPV DNA检出率为19%(19/100),其中HPV16 DNA感染率15%(15/100),HPV58 DNA感染率3%(3/100),HPV18 DNA感染率2%(2/100),HPV 16与HPV18双重感染1例。结论:本地区成年女性HPV感染主要以HPV16多见,而HPV16与恶性肿瘤密切相关,因此对HPVDNA阳性者定期随访,有利于宫颈癌的防治。
OBJECTIVE: To investigate the distribution of human papillomavirus (HPV) and its genotypes in adult women in Lanzhou, and to provide a theoretical basis for the study of HPV molecular epidemiology in this area. Methods: HPV genotypes were detected in 100 gynecological clinic patients by PCR technique. Results: The detection rate of HPV DNA was 19% (19/100) in 100 samples, among which HPV16 DNA infection rate was 15% (15/100), HPV58 DNA infection rate was 3% (3/100), HPV18 DNA infection rate 2% (2/100), HPV 16 and HPV18 double infection in 1 case. Conclusion: HPV16 is more common in adult women in this area than HPV16. HPV16 is closely related to malignant tumors. Therefore, regular follow-up of HPV DNA positive patients is helpful for the prevention and treatment of cervical cancer.