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目的观查周期型马来丝虫在小白鼠体内发育和病理变化.方法每只鼠腹腔内注射从东乡伊蚊收集60?200条感染期幼虫,定期抽查微丝蚴并解剖观察病理变化.结果在感染后30?310天解剖分别检获Ⅳ期幼虫.童虫和成虫,成虫阳性率为34.62％(9/26),主要病变为淋巴管炎、淋巴结炎,及其周围炎,在肺、脾、睾丸和精索可见淋巴栓塞,合有成虫和炎细胞,肺部可见退行性变的成虫和幼虫,形成丝虫性肉芽肿性病变.结论结果证实马来丝虫经沙鼠再传至小白鼠体内可发育到成虫并产生微丝蚴,可用以抗丝虫药物筛选,免疫学和病理变化等研究.“,”AIM To observe the development and histopathology of the periolic Brugia malayi with experimental infection in white mice. METHODS Each mouse was peritoneally inoculated with 60- 200 infective filarial larvae from Aedes togoi mosquitoes. After infection peritoneal fluid was collected and the mice were sacrified at various intervals to study the development of B. malayi in white mice. RESULT At 30- 310d after infection, the 4th stage larvae as well as juveniles and adult worms were collected from mice. The recovered rate of the adult worms was 34. 62% (9/26). The main histopathologic changes were lymphangitis,lymphadenitis and Perk lymphatic inflammation. In the lung,spleen, testis, and spermatic cord existed lymphathrombus, some contained adult worms and inflammatory cells. Granulomatous could be found in the lung containing disintegrating adult worms or larvae. CONCLUSION The results indicated that B. Malayi could develop to mature stage adult and reproduce microfilariae in Kunming strain mice. It could be used to study on screening of antifilarial drug,immunology and pathology.