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为评价三价口服脊髓灰质炎疫苗(TOPV)的免疫效果,作者在1988年5月～1989年5月在印度马德拉斯市对6～35月龄儿童中进行了一项病例对照研究。 所有病例都是居住于马德拉斯市的急形麻痹性脊髓灰质炎患儿,并在儿童健康研究所(国家脊髓灰质炎监测中心)作住院治疗,他们代表该市95％的病例。病例诊断依据临床表现并经粪便培养证实,病毒分离阳性率为60％。对照组选自该研究所的门诊轻微疾病(上呼吸道感染、发热和腹泻等)病例,年龄和性别与研究组相似,且也是马德拉斯市居民。
To evaluate the immunogenicity of the trivalent oral polio vaccine (TOPV), the authors conducted a case-control study of children aged 6-35 months in Madras, India, from May 1988 to May 1989. All cases were children with acute paralytic poliomyelitis living in Madras and were hospitalized at the Institute for Child Health (National Polio Surveillance Center), representing 95% of the city’s cases. Case diagnosis based on clinical manifestations confirmed by fecal culture, the positive rate of virus isolation was 60%. The control group was selected from the Institute’s outpatient minor illness (upper respiratory tract infection, fever and diarrhea), age and gender similar to the study group, and is also a resident of Madras.