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用人胎支气管上皮细明研究了苯并(a)芘(BaP)5种代谢物诱发程序外DNA合成和微核形成的能力。结果显示,除syn-BPDE外,所有代谢物都能诱发人支气管上皮细胞的UDS和MN,但anti-BPDE的作用最强,它可能是BaP的一种最终致癌代谢物,在人类肺癌的病因中起重要作用。
The ability of five metabolites of benzo (a) pyrene (BaP) to induce DNA synthesis and micronuclei formation outside the program was investigated using human fetal bronchial epithelium. The results showed that all the metabolites, except syn-BPDE, induced UDS and MN in human bronchial epithelial cells, but anti-BPDE was the most potent and may be one of the ultimate carcinogenic metabolites of BaP in the pathogenesis of human lung cancer Play an important role.