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猪圆环病毒2型(Porcine circovirus type 2,PCV2)是引起断奶仔猪多系统衰竭综合征(Postweaning multisystemic wasting syndrom,PMWS)的主要病原,对全球养猪业造成极大的经济损失。目前的免疫策略主要基于病毒的衣壳蛋白。研究表明,猪圆环病毒衣壳蛋白具有体外自组装成病毒样颗粒的能力。本文就病毒样颗粒(virus-like particles,VLPs)的特点及PCV2疫苗的研究现状做以综述。并探讨了基于VLP的PCV2疫苗的发展前景。
Porcine circovirus type 2 (PCV2) is the major causative agent of postweaning multisystemic wasting syndrom (PMWS), causing great economic losses to the global pig industry. The current immunization strategy is mainly based on the viral capsid protein. Studies have shown that porcine circovirus capsid proteins have the ability to self-assemble into virus-like particles in vitro. This review summarizes the characteristics of virus-like particles (VLPs) and the current status of PCV2 vaccines. And discussed the prospect of PCV2 vaccine based on VLP.