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目的:观察小剂量红霉素治疗早产儿胃食管反流的疗效。方法:对65例早产胃食管反流患儿随机分为两组,治疗组30例用小剂量红霉素治疗,对照组35例用东莨菪碱治疗,治疗一个疗程后根据患儿体重增长情况判定疗效。结果:治疗一个疗程(10 d)后观察患儿体重变化,治疗组治疗前后比较,体重增加有明显差异(t=8.78;P<0.01);对照组体重变化不大,无统计学差异(t=1.94;P>0.05)。两组每日平均体重增加情况比较也有明显差异(t=4.92;P<0.01)。结论:小剂量红霉素对早产儿胃食管反流治疗有显著疗效,优于东莨菪碱等传统解痉药物。
Objective: To observe the efficacy of low dose erythromycin in the treatment of gastroesophageal reflux in premature infants. Methods: Sixty-five children with preterm gastro-oesophageal reflux were randomly divided into two groups. The treatment group was treated with low-dose erythromycin and the control group with scopolamine. After a course of treatment, the curative effect was determined according to the weight gain of the child . Results: The change of body weight was observed after one course of treatment (10 days). The body weight of the treatment group before and after treatment was significantly different (t = 8.78; P <0.01); the body weight of the control group did not change much, and there was no significant difference = 1.94; P> 0.05). There was also a significant difference between the two groups in daily average weight gain (t = 4.92; P <0.01). Conclusion: The low dose of erythromycin has a significant effect on the treatment of gastroesophageal reflux in premature infants, which is superior to the traditional antispasmodic drugs such as scopolamine.