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目的：了解江苏部分地区人群中谷胱甘肽转硫酶ＧＳＴＭ_１和ＧＳＴＴ_１基因多态性与大肠癌易患性的关系。方法：应用多重ＰＣＲ法．对照研究５５例大肠癌患者和６２例健康人的ＧＳＴＭ_１和ＧＳＴＴ_１基因频率。结果：在健康对照和大肠癌病例中，ＧＳＴＭ_１基因缺失频率分别为５３．２％和６１．８％，ＧＳＴＴ_１基因缺失频率分别为５０．０％和５６．４％，病例组基因缺失频率高于健康对照组，但无显著性差异（Ｐ＞０．０５）。结论：ＧＳＴＭ_１和ＧＳＴＴ_１基因缺失与大肠癌易患性和发病年龄无明显相关性。
OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase GSTM 1 and GSTT 1 genes and susceptibility to colorectal cancer in population in some regions of Jiangsu. Methods: Application of multiplex PCR. Controlled studies of GSTM 1 and GSTT 1 gene frequencies in 55 patients with colorectal cancer and 62 healthy controls. RESULTS: In the healthy controls and colorectal cancer cases, the frequency of GSTM 1 gene deletion was 53.2% and 61.8%, and the frequency of GSTT 1 gene deletion was 50.0% and 56.4%, respectively. The frequency of gene deletion was higher in the case group. Healthy control group, but no significant difference (P> 0.05). Conclusion: There is no significant correlation between GSTM 1 and GSTT 1 gene deletion and susceptibility and age of onset of colorectal cancer.