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多伦多消息:据多伦多韦尔斯利医院皮肤病学家Norman Shiffman说,Isotretinoin对治疗严重的结节型囊性痤疮有很好的疗效。在韦尔斯利医院第15届临床日年会上,Shiffman说:“1979年Peck曾首次报道Isotretinoln以每日每公斤体重2毫克的剂量连续用16个星期,延长了囊状和结节状痤疮的缓解期。此后几项双盲对比研究都进一步证实了上述这些发现。当药物剂量比Peck用的剂量低得多的情况下,药物仍有效,而且在停药以后仍能长期维持缓解。虽然此药有一些可厌的副作用,但比较安全。极重要的是此药的致畸作用。
TORONTO (Reuters) - Isotretinoin works well for the treatment of severe nodular cystic acne, according to Norman Shiffman, a dermatologist at Wellesley Hospital in Toronto. Shiffman said at Wellesley’s 15th Annual Clinical Clinic: "In 1979, Peck reported for the first time that Isotretinol extended the cystic and nodular appearance for 16 weeks at a dose of 2 mg / kg body weight per day for 16 consecutive days Acne remission, several of these double-blind comparative studies have further confirmed the above findings.When the drug dose is much lower than the dose Peck, the drug is still effective, and long-term maintenance of remission after withdrawal. Although this medicine has some unpleasant side effects, it is safer, and extremely important is the teratogenic effect of this medicine.