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目的研究淋巴瘤患者确诊时和治疗前后的血红蛋白(Hb)变化和贫血发生情况及其与临床分期、年龄和治疗等方面的关系。方法对我院近10年的住院94例淋巴瘤患者进行回顾分析,研究治疗前后Hb值的变化和贫血的发生例数,并按临床分期和年龄分组进行分析。结果①94例患者确诊时发生贫血例数为46例(48.9%),总贫血发生为80例(85.1%)P<0.001。I级34例和II级33例,明显高于III级4例和IV级9例。②年龄分组各组治疗后的Hb值明显低于治疗前的Hb值,分别为P<0.01,P<0.05和P<0.005;而分期各期治疗后的Hb值明显也低于治疗前,有显著差异(分别为P<0.01,P<0.05)。随着分期的提高,贫血发生率增高,P<0.001。③贫血发生与年龄、临床分期有密切的关系(P<0.01)。结论淋巴瘤患者有较高的贫血发生率,贫血的发生与临床分期和患者年龄密切相关。
Objective To study the changes of hemoglobin (Hb) and anemia in patients with lymphoma at diagnosis and before and after treatment and their relationship with clinical stage, age and treatment. Methods A retrospective analysis was performed on 94 cases of inpatients with lymphoma in our hospital in recent 10 years. The changes of Hb value and the number of anemia before and after treatment were studied and analyzed by clinical stage and age group. Results ① The number of anemia cases in 94 patients was 46 (48.9%) and the total anemia was 80 (85.1%) P <0.001. 34 cases of grade I and 33 cases of grade II, which were significantly higher than those of grade 4 and 9. (2) The Hb value of each group after treatment was significantly lower than that before treatment (P <0.01, P <0.05 and P <0.005, respectively); while the Hb value of each stage after treatment was significantly lower than that before treatment Significant differences (P <0.01, P <0.05, respectively). With the increase of staging, the incidence of anemia increased, P <0.001. ③ anemia and age, clinical stage are closely related (P <0.01). Conclusions Patients with lymphoma have a higher incidence of anemia. The occurrence of anemia is closely related to clinical stage and patient’s age.