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哌嗪盐类在中国药典(1963年版)、美国药典(18版)和英国药典(1973年版)等大都采用重量法测定含量,但此法操作繁杂,而且又费时间。今参考外地经验改用容量法(即剩余络合量法)测定,具有操作容易掌握、省时、终点明显等优点。该方法如下:试液的配制:(1)硝酸铋试液:取硝酸铋48.5g于烧杯中,加硝酸28ml,温热使溶解,加蒸溜水稀释成1000ml,即得。(2)二甲酚橙指示液:取二甲苯酚橙0.2g,用蒸溜水溶解成100ml 即得。
Piperazine salts were determined gravimetrically in the Chinese Pharmacopoeia (1963), the United States Pharmacopoeia (18) and the British Pharmacopoeia (1973), but this method was cumbersome and time-consuming. This reference to the field experience to capacity method (that is, the amount of residual complex method) determination, with easy to grasp the operation, save time, the end point obvious advantages. The method is as follows: Preparation of the test solution: (1) bismuth nitrate test solution: Take 48.5g of bismuth nitrate in a beaker, add nitric acid 28ml, warm to dissolve, add distilled water diluted to 1000ml, that is. (2) xylenol orange indicator solution: Take xylenol orange 0.2g, dissolved in distilled water into 100ml that was.