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结直肠癌(CRC)是男女性中均常见的高死亡率恶性肿瘤,仅美国每年就有56 000例的新发病例。Rath-Wolfson L等人观察了CRC发病率在男女性之间的差异,同时检测了肿瘤组织和癌旁结肠黏膜组织中雌激素受体β1表达情况,并分析其判断预后的价值。该研究选取了55例接受结肠癌切除术患者的手术切除标本并行免疫组化染色,分别对肿瘤组织及正常的结肠黏膜组织的染色结果进行统计分析。结果发现,肿瘤细胞中雌激素受体β1表达阳性产物位于细胞核和细胞质;正常的结
Colorectal cancer (CRC) is a high-grade malignancy that is common in both men and women, with 56,000 new cases occurring each year in the United States alone. Rath-Wolfson L et al observed the incidence of CRC in men and women differences between the same time, the detection of tumor tissue and adjacent mucosa tissue adjacent to estrogen receptor β1 expression and analysis of its prognostic value. The study selected 55 cases of colon resection patients underwent surgical resection specimens parallel immunohistochemical staining, respectively, the tumor tissue and normal colonic mucosa staining results were statistically analyzed. The results showed that tumor cells estrogen receptor β1-positive products located in the nucleus and cytoplasm; normal knot