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早在60年代,我们发现活血化淤药丹参能够延长Ehrlich腹水癌小鼠的存活期。在以后的年代里曾发现活血化淤药对血栓闭塞性脉管炎患者的纤溶状态有良好的影响,根据这项工作的启示,设想丹参的抗癌机理是否与其对机体的纤溶状态的影响有关,实验证明:丹参能够在体外促进犬血的纤溶作用。我们还通过对血栓性静脉炎临床资料分析,探讨了恶性肿瘤与血栓性静脉炎的关系,复习了肿瘤患者的凝血、纤溶状态的紊乱及其临床意义的有关文献。
As early as the 1960s, we found that salvia miltiorrhiza which can activate blood stasis can prolong the survival of mice with Ehrlich ascites. In later years, it was found that blood stasis drugs have a good influence on the fibrinolytic status of patients with thromboangiitis obliterans. Based on the enlightenment of this work, it is assumed whether the anti-cancer mechanism of Salvia miltiorrhiza is related to the fibrinolytic state of the body. The effects are relevant and experiments have shown that Salvia miltiorrhiza can promote fibrinolysis of canine blood in vitro. We also analyzed the clinical data of thrombophlebitis, discussed the relationship between malignant tumors and thrombophlebitis, and reviewed the literature on coagulation and fibrinolytic disorders in patients with cancer and their clinical significance.