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通过配体交换的方法成功将含糖聚合物PGAMA14-PCL32-SH接枝到纳米金棒的表面(Gly@AuNRs).借助X-射线光电子能谱(XPS)、动态光散射(DLS)、热重分析(TGA)等对Gly@AuNRs进行了表征.为了得到药物控释所需要的合适的实验条件,研究了近红外光照射下Gly@AuNRs在水溶液中的光热转换行为.用Gly@AuNRs包裹药物姜黄素(CUR),研究了药物的体外释放,发现近红外光能有效控制药物的体外释放.细胞实验结果表明含糖聚合物的接枝大大提高了纳米金棒的生物相容性.因此,Gly@AuNRs复合材料能够作为生物相容性载体材料,并实现近红外光触发的药物的可控释放.
The glycosylated polymer PGAMA14-PCL32-SH was successfully grafted to the surface of gold nanorods by means of ligand exchange method.According to X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS) Gly (Au) AuNRs were characterized by TGA, etc. In order to get the suitable experimental conditions needed for drug controlled release, the light-to-heat conversion behavior of Gly @ AuNRs in aqueous solution under near infrared light irradiation was studied. The drug curcumin (CUR) was used to study drug release in vitro and found that near-infrared light can effectively control drug release in vitro.The results of cell experiments showed that the grafting of sugary polymer greatly enhanced the biocompatibility of nano- Gly @ AuNRs composites can be used as biocompatible support materials and achieve controlled release of near-infrared light-triggered drugs.