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目的:观察在经皮冠状动脉介入治疗(PCI)术前常规疗法基础上加用参麦注射液治疗急性心肌梗死患者的效果。方法:将100例急性心肌梗死行PCI治疗的患者,随机分为观察组与对照组各50例,对照组手术前后均采用常规治疗,观察组在此基础上,术前给予参麦注射液静脉滴注,比较2组患者治疗前后的心功能分级、左室功能[左室舒张末内径(LVDD)、左室收缩末内径(LVESD)、左室射血分数(LVEF)]、脑钠肽(BNP)、肌酸激酶同工酶(CK-MB)及肌钙蛋白T(c Tn T)的浓度变化,统计2组患者的术后不良心血管事件发生率。结果:2组PCI术前心功能分级情况比较,差异无统计学意义(P>0.05)。治疗后,观察组心功能分级与治疗前比较,差异有统计学意义(P<0.05);对照组治疗前后心功能分级比较,差异无统计学意义(P>0.05);2组心功能分级情况比较,差异有统计学意义(P<0.05)。术后3月时,2组LVDD、LVESD及LVEF均得到明显改善,与治疗前比较,差异均有统计学意义(P<0.05);观察组LVDD、LVESD值均低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05)。术后1天,2组BNP、CK-MB及c Tn T浓度均较治疗前升高(P<0.05);术后7天,2组BNP、CK-MB及c Tn T浓度均较治疗前与术后1天下降(P<0.05),观察组各项指标值均低于对照组,差异均有统计学意义(P<0.05)。观察组不良心血管事件发生率低于对照组(P<0.05)。结论:在PCI术前常规治疗基础上加用参麦注射液,可有助于改善急性心肌梗死患者的心功能、保护受损心肌组织,减少不良心血管事件发生率。
Objective: To observe the effect of adding shenmai injection on patients with acute myocardial infarction after percutaneous coronary intervention (PCI) preoperative routine therapy. Methods: A total of 100 patients with acute myocardial infarction undergoing PCI were randomly divided into observation group (50 cases) and control group (50 cases). The control group received routine treatment before and after operation. On the basis of this observation, (Left ventricular end-diastolic diameter (LVDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)], brain natriuretic peptide BNP, CK-MB and cTn T were measured. The incidence of adverse cardiovascular events in two groups were calculated. Results: There was no significant difference in the grading of cardiac function between two groups before PCI (P> 0.05). After treatment, heart function grading in observation group compared with before treatment, the difference was statistically significant (P <0.05); control group before and after treatment of cardiac function comparison, the difference was not statistically significant (P> 0.05); 2 groups of cardiac function classification The difference was statistically significant (P <0.05). At 3 months after operation, LVDD, LVESD and LVEF were significantly improved in both groups, with statistical significance (P <0.05), and LVDD and LVESD values in the observation group were significantly lower than those in the control group Control group, the difference was statistically significant (P <0.05). After 1 day, the concentrations of BNP, CK-MB and cTnT in two groups were significantly higher than those before treatment (P <0.05). After 7 days, the concentrations of BNP, CK-MB and cTnT in two groups were significantly higher than those before treatment And one day after operation (P <0.05). The indexes in the observation group were lower than those in the control group, with statistical significance (P <0.05). The incidence of adverse cardiovascular events in the observation group was lower than that in the control group (P <0.05). Conclusion: Adding Shenmai injection on the basis of routine preoperative treatment of PCI can improve the cardiac function, protect the damaged myocardial tissue and reduce the incidence of adverse cardiovascular events in patients with acute myocardial infarction.