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血管紧张素转换酶2(ACE2)是肾素血管紧张素系统(RAS)的新成员,它是迄今为止发现的第一个人血管紧张素转换酶(ACE)相关的同系物。ACE降解血管紧张素Ⅰ(AngⅠ)生成血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)。而ACE2的主要作用是降解AngⅡ,生成具有强舒血管作用的多肽-血管紧张素-(1～7)。在RAS中,ACE2与ACE可能发挥相反的作用,从而维持RAS的稳定。ACE2与ACE在结构及肾脏中的分布均有相似及不同之处。ACE2在肾脏中高度表达,它在肾脏的生理及病理状态中均扮演重要角色。对ACE2基因剔除及应用ACE2抑制剂模型的研究表明,ACE2可能对肾脏有保护作用,通过促进ACE2的表达或摄入外源性ACE2来提高ACE2水平可能为肾脏疾病的治疗提供新的研究方向。
Angiotensin-converting enzyme 2 (ACE2) is a new member of the renin-angiotensin system (RAS), the first human angiotensin-converting enzyme (ACE) -related homologue discovered to date. ACE degrades angiotensin Ⅰ (Ang Ⅰ) to produce angiotensin Ⅱ (Ang Ⅱ). The main role of ACE2 is to degrade Ang Ⅱ, generating a strong vasodilator peptide - angiotensin - (1 ~ 7). In RAS, ACE2 and ACE may play the opposite role, thus maintaining the stability of RAS. ACE2 and ACE in the structure and distribution of the kidney are similar and different. ACE2 is highly expressed in the kidney and plays an important role in the physiology and pathology of the kidney. ACE2 gene knockout and application of ACE2 inhibitor model studies have shown that ACE2 may have a protective effect on the kidneys, ACE2 by promoting the expression of ACE2 or exogenous ACE2 to improve ACE2 levels may provide new directions for the treatment of kidney disease.