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目前,肥胖在世界呈流行趋势,严重威胁人类健康〔1〕,被世界卫生组织列为导致疾病负担的十大危险因素之一〔2〕。而代谢和心脑血管疾病仍是危害人类健康和生命最危险因素。B型脑钠肽(BNP)主要由心室细胞合成分泌,存在于心肌的分泌颗粒中,心室负荷和室壁张力的改变刺激BNP分泌〔3
Currently, obesity in the world is a popular trend, a serious threat to human health 〔1〕, the World Health Organization as one of the top ten risk factors leading to the burden of disease 〔2〕. Metabolic and cardiovascular diseases are still the most dangerous factors that endanger human health and life. B-type brain natriuretic peptide (BNP) is mainly synthesized and secreted by ventricular cells and exists in secretory granules of cardiac muscle. The changes of ventricular load and wall tension stimulate the secretion of BNP [3