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调查成年癫痫患者服用传统抗癫痫药物 (AED)对生活质量 (QOL)的影响。方法 :采用癫痫生活质量 - 10问卷 (QOLIE - 10 )对 2 0 0例在过去一年服用传统AED的成年癫痫患者 ,药物分组为单药组CZP组、PHT组和VPA组。多药组分为二种AED组和三种以上AED组。未用AED组 ,对照组 ,进行了药物的副反应、发作频率和QOL的调查。结果 :AED组和未用AED组与对照组比较差异非常显著P <0 .0 1。单药组副反应和QOL的组间比较无显著性 ,发作频率PHT组明显减少。多药组中三种以上AED组的副反应、发作频率和QOL都比其他组要差 ,P <0 .0 1。结论 :癫痫患者的QOL降低十分明显 ,以三种以上AED联合使用其QOL更差 ,不能排除难治性癫痫的因素。
To investigate the effect of taking traditional antiepileptic drugs (AED) on quality of life (QOL) in adults with epilepsy. Methods: Two hundred and seventy adult epilepsy patients who took the traditional AED in the past year were divided into single drug group CZP group, PHT group and VPA group by QOLIE - 10 questionnaire. Multi-drug components are two AED groups and three or more AED groups. In the AED group and the control group, side effects of the drugs, seizure frequency and QOL were investigated. Results: The difference between AED group and non-AED group and control group was significant (P <0.01). There was no significant difference between the side effects and QOL in the single drug group, and the frequency of the attack was significantly reduced in the PHT group. More than three groups of multi-drug AED side effects, seizure frequency and QOL worse than the other groups, P <0. CONCLUSIONS: The QOL reduction in patients with epilepsy is very significant. The combination of more than three AEDs results in poorer QOL and can not rule out refractory epilepsy.