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瘦素(leptin)主要是由白色脂肪细胞分泌的一种小分子蛋白质,其受体广泛表达于乳腺、结肠和肺等器官中。最初关于瘦素的研究主要是基于肥胖及其相关机制方面的研究。近年来研究发现瘦素与多种肿瘤的发生、发展有密切关系。恶性胸腔积液的发生主要与癌细胞在胸膜转移浸润和局部产生炎症反应导致血管通透性增加有关。本文就瘦素与恶性胸腔积液的关系作一综述。
Leptin is mainly a small molecule protein secreted by white adipocytes. Its receptors are widely expressed in organs such as breast, colon and lung. The initial study of leptin was based primarily on studies of obesity and its associated mechanisms. In recent years, studies have found that leptin and a variety of tumor occurrence and development are closely related. The occurrence of malignant pleural effusion mainly associated with cancer cells in the pleural metastasis infiltration and local inflammation caused by increased vascular permeability. This article reviews the relationship between leptin and malignant pleural effusion.