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遗传性凝血疾病(HCD) 东南亚国家HCD的流行情况或多或少类似于西方国家。1977-1979年泰国对血友病流行作了全国性调查,结果为1/1.3-2万。多数为血友病甲、乙,血管性假血友病和遗传性血小板机能障碍。血友病甲、乙、丙的发病率分别为84%,12%和4%。血管性假血友病与血友病的比例的1∶6。遗传性因子Ⅰ、Ⅱ、Ⅴ、Ⅶ、Ⅻ、Ⅷ也已有少数病例报道。泰国对HCD治疗使用最多的血液成分是FFP、冰冻冷沉淀和FDP(新鲜冻干血浆)。目前全国甚至乡村医院都广泛使用FDP替代FFP作为治疗血液凝固性疾病、补充血浆蛋白、扩张血浆和急性失血及登革出血热伴低血容量性休克时替代血容量。获得性凝血疾病 1.感染引起出血的感染有登革出血热、疟疾、细菌性败血症、原虫和病毒感染、急性暴发性肝炎
Hereditary coagulopathy (HCD) The prevalence of HCD in Southeast Asian countries is more or less similar to Western countries. From 1977 to 1979, Thailand conducted a nationwide survey of the prevalence of hemophilia, with a result of 1 in 13,000 to 20,000. Mostly hemophilia A, B, von Willebrand’s disease and hereditary platelet dysfunction. The incidence of hemophilia A, B and C were 84%, 12% and 4%, respectively. The ratio of von Willebrand disease to hemophilia is 1: 6. Hereditary factors Ⅰ, Ⅱ, Ⅴ, Ⅶ, Ⅻ, Ⅷ have also been reported in a few cases. The most commonly used blood components for HCD treatment in Thailand are FFP, cryo-precipitation and FDP (fresh lyophilized plasma). At present, FDP is widely used in rural hospitals throughout the country as an alternative to FFP for the treatment of blood coagulation disorders, replacement of plasma proteins, expansion of plasma and acute blood loss, and dengue hemorrhagic fever with hypovolemic shock. Acquired coagulopathy 1. Infections Bleeding-causing infections include dengue haemorrhagic fever, malaria, bacterial sepsis, protozoal and viral infections, acute fulminant hepatitis