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本实验对白三烯在大白鼠缺氧性肺血管收缩反应(HPV)中的作用进行了研究。结果发现脂氧酶抑制剂枸橼酸乙胺嗪(DEC)可明显地抑制活体大鼠的HPV,对血管紧张素Ⅱ的缩血管作用无明显影响。单独应用环氧酶抑制剂消炎痛可使HPV增强;予先用消炎痛或扑尔敏也不改变DEC对HPV的抑制作用。说明本实验所用DEC抑制HPV的作用与血管紧张素,前列腺素和组胺无关。白三烯受体拮抗剂FPL55712可明显或完全阻断Hilltop和SD大白鼠的HPV,进一步证明白三烯很可能是大白鼠HPV中最主要的介导者。
The experiment on leukotriene hypoxic pulmonary vasoconstriction in rats (HPV) in the role of research. The results showed that lipoxygenase inhibitor diethylcarbamazine (DEC) can significantly inhibit the in vivo rat’s HPV, angiotensin II vasoconstrictor effect was not significantly affected. Indomethacin, an epoxidease inhibitor alone, increased HPV; preinjection with indomethacin or chlorpheniramine did not alter the inhibitory effect of DEC on HPV. This experiment used to inhibit the role of DEC inhibition of HPV and angiotensin, prostaglandins and histamine has nothing to do. Leukotriene receptor antagonist FPL55712 can significantly or completely block the HPV of Hilltop and SD rats, further demonstrating that leukotrienes are likely to be the most important mediators of HPV in rats.