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阴道黏膜上皮构成了人体防御病毒和细菌侵袭的天然屏障,同时也可能由于药物、化妆品、女性护理品、避孕器具和杀菌剂的使用造成局部刺激性等副作用,进而造成阴道黏膜上皮损伤和极易感染各种病菌。因此,检测与人体黏膜接触物质的刺激性是产品质量安全性评价的关键。目前法规认可的方法是兔体内阴道黏膜刺激实验(RVI模型),适用于计生用品、卫生用品和杀菌剂等产品的评估。然而,动物实验对于其他种类的贴身护理品的安全评估则有所欠缺,如婴儿纸
Vaginal mucosal epithelium constitutes a natural barrier to the body’s defense against viruses and bacteria, but also may cause side effects such as local irritation due to the use of drugs, cosmetics, feminine care products, contraceptives and bactericides, which in turn may lead to vaginal mucosal epithelial damage and extremely easy Infected with various germs. Therefore, the detection of human mucosal contact with the material irritation is the key to product quality and safety evaluation. At present, the approved method is the vaginal mucosal stimulation test in rabbits (RVI model), which is applicable to the evaluation of products such as family planning products, hygiene products and bactericides. However, there is a lack of safety evaluation of animal experiments for other types of personal care products, such as baby paper