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目的 建立一种食品包装材料中双酚S含量的检测方法。方法 通过考察不同的提取方式、提取溶剂和提取温度,最后采用甲醇对食品包装材料进行超声提取,并将提取液过滤膜后直接进行超高效液相色谱-串联三重四极杆质谱分析;通过优化色谱-质谱仪器参数,最终采用多反应模式(MRM)进行定量检测。结果该方法检出限为0.10 mg/kg,定量限为0.30 mg/kg,在0.50~20 mg/kg范围内线性良好(相关系数为0.9993)。通过对空白样品进行双酚S的加标回收实验,结果表明平均回收率为89.6%~95.1%,相对标准偏差为3.1%~7.9%。结论 该方法灵敏度高、抗干扰性强、重现性好,可用于常见食品包装材料中双酚S的含量检测。
Objective To establish a method for the determination of bisphenol S in food packaging materials. Methods The different extraction methods were investigated, the solvent and extraction temperature were extracted. Finally, the food packaging material was extracted with methanol by ultrasonic and the extract was filtered and directly analyzed by ultra performance liquid chromatography-tandem triple quadrupole mass spectrometry. Chromatography - mass spectrometry parameters, the final multi-reaction mode (MRM) for quantitative detection. Results The detection limit was 0.10 mg / kg and the limit of quantification was 0.30 mg / kg. The linearity was good in the range of 0.50 ~ 20 mg / kg (correlation coefficient was 0.9993). The results of spiked recovery of bisphenol S by blank samples showed that the average recovery was 89.6% ~ 95.1% and the relative standard deviation was 3.1% ~ 7.9%. Conclusion The method has high sensitivity, strong anti-interference, good repeatability and can be used for the determination of bisphenol-S in common food packaging materials.