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目的:探讨阴道上皮内瘤变(VAIN)的临床特征及采用激光联合干扰素局部治疗的临床疗效。方法:选择2006年5月～2010年12月重庆市妇幼保健院宫颈专科门诊经组织学确诊的VAIN患者21例,总结其临床特征,分析人乳头瘤病毒(HPV)感染状况,采用激光联合阴道给药重组人干扰素α-2b凝胶治疗,随访12个月以上,评价临床疗效。结果:①21例VAIN患者高危型HPV感染率为100.00%,其中HPV16型感染最常见(61.90%,13/21);②病灶多呈多灶性分布(71.43%,15/21),主要位于阴道穹窿部及阴道侧壁上1/3段(90.48%,19/21);③激光联合干扰素局部治疗VAIN临床治愈率为80.95%(17/21),好转率为14.29%(3/21),无效率为4.76%(1/21),复发率为19.05%(4/21)。术后并发症少,无阴道壁瘢痕形成,无阴道大量出血,无阴道粘连发生。结论:高危型HPV感染与VAIN发生密切相关,激光联合干扰素局部用药治疗VAIN,安全有效,近期疗效明确,远期疗效仍需观察。
Objective: To investigate the clinical features of vaginal intraepithelial neoplasia (VAIN) and the clinical efficacy of laser combined with local interferon therapy. Methods: From May 2006 to December 2010, 21 males and females with VAIN diagnosed by Department of Cervical Surgery, Chongqing MCH Hospital from January 2006 to December 2010 were retrospectively reviewed. Their clinical characteristics were analyzed. The infection status of human papillomavirus (HPV) Administration of recombinant human interferon alpha-2b gel treatment, followed up for 12 months, evaluate the clinical efficacy. Results ① The prevalence of high-risk HPV was 100.00% in 21 patients with VAIN, of which HPV16 infection was the most common (61.90%, 13/21); ② The lesions were mostly multifocal (71.43%, 15/21) (90.48%, 19/21) on the vault and vaginal wall; (3) The clinical cure rate of VAIN with laser combined with interferon was 80.95% (17/21), the improvement rate was 14.29% (3/21) , The inefficiency was 4.76% (1/21), the recurrence rate was 19.05% (4/21). No postoperative complications, no vaginal wall scar formation, no vaginal bleeding, no vaginal adhesions. Conclusion: High-risk HPV infection is closely related to the occurrence of VAIN. Topical application of laser combined with interferon in the treatment of VAIN is safe and effective. The short-term curative effect is clear. The long-term curative effect still needs to be observed.