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目的 了解子宫内膜异位症 (内异症 )患者血清和腹腔液CA12 5水平以及在腹腔镜保守性手术治疗后的变化。方法 收集内异症 3 0例的腹腔镜保守性手术的血清和腹腔液 ,并以经腹腔镜检查确诊为与内异症无关病例 1 0例为对照 ,应用免疫酶标反应测定CA12 5水平。结果 内异症患者血清和腹腔液CA12 5水平高于对照组 ,并随病情的加重而升高 ,但在腹腔镜保守性手术后显著下降 ;在R AFSⅠ Ⅱ期内异症患者检测高倍稀释( 1∶1 0 0 )腹腔液CA12 5水平比检测血清CA12 5更敏感。结论 血清和腹腔液CA12 5值在术后随访、监测及估价手术方法的彻底性和有效性方面有重要价值 ;检测高倍稀释 ( 1∶1 0 0 )腹腔液CA12 5水平 ,可避免与对照组之间可能存在的血清CA12 5“交叉” ,及检测未稀释腹腔液标本时存在的“HOOK效应”。提出术后后穹窿穿刺获取腹腔液的可行性
Objective To investigate the serum and peritoneal CA12 5 levels in patients with endometriosis (endometriosis) and their changes after laparoscopic conservative surgery. Methods Serum and peritoneal fluid collected from laparoscopic conservative surgery of 30 cases of endometriosis were collected and compared with 10 cases unrelated to endometriosis diagnosed by laparoscopy. The level of CA12 5 was measured by immunoenzyme reaction. Results Serum and peritoneal CA12 5 levels in patients with endometriosis were higher than those in control group and increased with the severity of the disease. However, the levels of CA12 5 in patients with endometriosis were significantly decreased after laparoscopic conservative surgery. 1: 100) Peritoneal fluid CA12 5 levels are more sensitive than serum CA12 5. Conclusion Serum and peritoneal CA12 5 levels are of great value in follow-up, monitoring and evaluating the thoroughness and effectiveness of surgical methods. Detection of CA12 5 in peritoneal fluid at high dilution (1: 100) Between the possible presence of serum CA12 5 “cross”, and the detection of undiluted peritoneal fluid specimens exist “HOOK effect.” Postoperative posterior fornix puncture for peritoneal fluid feasibility