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目的探讨异丙酚复合芬太尼用于人工流产的镇痛效果及安全性。方法选取2008年德阳旗中医院施行异丙酚复合芬太尼人工流产术1162例为观察组,同期同孕周施行人工流产术未用镇痛药物270例为对照组,比较两组手术中、手术后疼痛感与出血情况及复经后月经情况;观察异丙酚复合芬太尼的麻醉诱导时间、恢复时间和手术前、手术中及恢复时的生命体征变化和药物不良反应。结果观察组受术者意识消失时间为(43.65±4.56)s,停药后意识恢复时间为(198.45±23.56)s,下床行走离开手术室时间为(8.76±1.67)min,术中血压、呼吸变化不大,无需特殊处理。与对照组比较,观察组术中无疼痛经历,术后明显疼痛发生率降低,差异有统计学意义(P<0.05);但两组手术时间,手术中出血量,术后疼痛持续时间,阴道流血时间及复经时间比较,差异无统计学意义(P>0.05)。结论异丙酚复合芬太尼用于人工流产镇痛效果满意,安全可靠。
Objective To investigate the analgesic effect and safety of propofol combined with fentanyl for induced abortion. Methods 1162 cases of induced abortion with fentanyl combined with fentanyl in Deyang Qi Chinese Medicine Hospital were selected as the observation group in 2008 and 270 cases of abortion-free analgesic drugs in the same period of gestation were used as the control group. During the operation, Postoperative pain and bleeding and postmenopausal menstruation; observation of propofol and fentanyl anesthesia induction time, recovery time and before surgery, surgery and recovery of vital signs and adverse drug reactions. Results The time of consciousness disappearing in the observation group was (43.65 ± 4.56) s, the recovery time was (198.45 ± 23.56) s, and the time to walk out of the operating room was (8.76 ± 1.67) min after operation. The intraoperative blood pressure, Breathe little change, no special treatment. Compared with the control group, the observation group had no history of pain during surgery, and the incidence of postoperative pain was significantly lower (P <0.05). However, the operation time, intraoperative blood loss, duration of postoperative pain, Bleeding time and recurrence time, the difference was not statistically significant (P> 0.05). Conclusion Propofol combined with fentanyl for analgesia induced by artificial abortion is satisfactory, safe and reliable.