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临床上常见严重创伤后出现多器官功能衰竭,由此而导致休克状态进行性加剧,危及患者生命,其中呼吸系统功能障碍——休克肺是突出变化之一,可对病人预后产主极为重要的影响。有报道川芎嗪对油酸和肾上腺素所导致的急性肺水肿有防治作用。我们观察了家兔肢体创伤后肺组织的变化和川芎嗪对肺损伤的影响。以探讨休克肺的发生机理及川芎嗪的防治效应。1 材料和方法1.1 动物及分组处理 实验用健康杂种家兔,体重2.5±0.5kg,雌雄兼用,25％乌拉坦腹腔注入麻醉(1g/
Multiple organ failures are common after severe trauma in clinical practice. As a result, the shock state is progressively increased and the patient’s life is endangered. Among them, respiratory system dysfunction—shock lung is one of the prominent changes, which can be extremely important for the patient’s prognosis. influences. It has been reported that tetramethylpyrazine has preventive and therapeutic effects on acute pulmonary edema caused by oleic acid and epinephrine. We observed the changes in lung tissue and the effects of tetramethylpyrazine on lung injury after limb trauma in rabbits. To investigate the mechanism of shock lung and the prevention and treatment of tetramethylpyrazine. 1 Materials and methods 1.1 Animals and groupings Experimental healthy hybrid rabbits, weighing 2.5 ± 0.5 kg, both male and female, 25% urethane intraperitoneal injection of anesthesia (1g/