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目的探讨完整切除术后ⅢA-N2期非小细胞肺癌(NSCLC)的预后因素。方法对2000年1月至2004年12月中山大学肿瘤防治中心收治的208例手术切除ⅢA-N2期NSCLC患者进行单因素生存分析和多因素分析。结果 208例手术切除的ⅢA-N2期NSCLC患者的中位生存期为769 d,1、2、3、4、5年的累计生存率分别为80.1%、55.2%、36.6%、29.2%和20.9%。利用Cox比例风险模型进行多因素分析发现术前血清癌胚抗原(CEA)、乳酸脱氢酶(LDH)水平和术后是否行辅助放、化疗是影响预后的独立因素。结论术前血清CEA、LDH水平和术后是否行辅助放、化疗是影响预后的重要因素。
Objective To investigate the prognostic factors of stage ⅢA-N2 non-small cell lung cancer (NSCLC) after complete resection. Methods One-way survival and multivariate analysis were performed on 208 patients with stage ⅢA-N2 NSCLC who were admitted to Sun Yat-sen University Cancer Center from January 2000 to December 2004. Results The median survival of 208 patients with stage ⅢA-N2 NSCLC was 769 days. The cumulative survival rates at 1, 2, 3, 4 and 5 years were 80.1%, 55.2%, 36.6%, 29.2% and 20.9 %. Multivariate analysis using the Cox proportional hazard model found that preoperative serum CEA, LDH levels and postoperative adjuvant radiotherapy and chemotherapy were independent prognostic factors. Conclusion Preoperative serum CEA, LDH levels and postoperative adjuvant radiotherapy, chemotherapy is an important factor affecting the prognosis.