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目的研究晚期非小细胞肺癌骨转移的骨相关事件(SRE)及其生存分析。方法回顾性研究自2002年2月~2006年1月间我院治疗的230例晚期非小细胞肺癌患者,评价其TNM分期、骨转移的诊断(放射性核素扫描、X线片、M R I、CT及PET-CT检查),比较肺癌不同分期骨相关事件的发生率及生存时间。结果在230例晚期非小细胞肺癌患者中发现骨转移70例(30.4%),其中SRE 35例(15.2%);Ⅲ期患者骨转移发生率14.7%(14/95)低于Ⅳ期41.5%(56/135),有统计学意义(P<0.01);但Ⅲ期患者骨转移合并SRE发生率与Ⅳ期相近,未见统计学意义(P>0.05)。无骨转移组患者平均存活时间高于有骨转移组,未合并SRE组患者存活时间长于合并SRE组,两组比较差异有统计学意义(P均<0.01)。结论在晚期非小细胞肺癌的治疗期间,临床上应尽早阻止骨相关事件的发生。
Objective To investigate the bone-related events (SRE) and survival analysis of bone metastases in patients with advanced non-small cell lung cancer. Methods A retrospective study of 230 patients with advanced non-small-cell lung cancer treated in our hospital from February 2002 to January 2006 was performed to evaluate the diagnosis of TNM staging and bone metastases (radionuclide scan, X-ray, MRI, CT And PET-CT examination, compared the incidence and survival time of different stages of bone-related events in lung cancer. Results Among 230 patients with advanced non-small cell lung cancer, 70 (30.4%) were found to have bone metastases, of which 35 were SRE (15.2%). The incidence of bone metastases in stage III patients was 14.7% (14/95) lower than 41.5% of stage IV. (56/135), statistically significant (P <0.01), but the incidence of bone metastases with SRE in stage III patients was similar to that in stage IV, with no statistical significance (P> 0.05). The average survival time of bone metastasis group was higher than that of bone metastasis group. The survival time of patients without SRE was longer than that of SRE group. There was significant difference between the two groups (P<0.01). Conclusion During the treatment of advanced non-small cell lung cancer, the occurrence of bone-related events should be prevented as early as possible.