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抗癌药物Ｖｍ－２６是一种拓朴异构酶（ＴｏｐｏｉｓｏｍｅｒａｓｅⅡ，ＴｏｐｏⅡ）及组蛋白Ｈｌ激酶的抑制剂。本文就其对Ｈｅｌａ细胞染色体形成的影响进行了观察。不同浓度的Ｖｍ－２６加入Ｈｅｌａ细胞培养液后４８小时，进行染色体制备，光镜观察。当Ｖｍ－２６的培养浓度在０．５－１．０μｇ／ｍｌ时，染色体的形成被阻断于分裂前期。当药物培养浓度于０．２５μｇ／ｍｌ时，可见有相当数量的细胞处于分裂前期，其胞核内具有不规则的染色质凝缩。另外，尚可见极少的分裂中期染色体集簇形成，但大都伴有染色体的结构异常。结果提示：Ｖｍ－２６可以通过抑制Ｈｅｌａ细胞染色体的形成，而影响细胞正常的分裂、繁殖。
Anti-cancer drug Vm-26 is a topoisomerase (Topoisomerase Ⅱ, Topo Ⅱ) and histone Hl kinase inhibitors. This article on its Hela cell chromosome formation was observed. Different concentrations of Vm-26 added to Hela cell culture medium 48 hours after chromosome preparation, light microscopy. When Vm-26 was cultured at a concentration of 0.5-1.0 μg / ml, the formation of chromosomes was blocked at the pre-division stage. When the concentration of drug culture at 0.25μg / ml, we can see a considerable number of cells in pre-division, the nucleus with irregular chromatin condensation. In addition, we can see very few metaphase chromosome cluster formation, but mostly associated with chromosomal structural abnormalities. The results suggest that Vm-26 can affect normal cell division and reproduction by inhibiting the formation of chromosomes in Hela cells.