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应用静脉注丙球(IVIG),配合抗生素(An)治疗重症感染新生儿12例,在观察疗效及不良反应的同时,通过检测患儿治疗前后T细胞亚群及白细胞介素Ⅱ(IL-2)产生水平的变化,观察IVIG对细胞免疫功能的影响。结果显示:患儿CD_3~+、CD_4~+、CD_8~+细胞及IL-2产生水平均明显低于正常同龄新生儿。经IVIG+An及单用An治疗后,T细胞各亚群及IL-2水平均明显增高。IVIG组与An组比较,诒疗后IVIG组CD_4~+细胞明显高于An组,IL-2水平也较An组为高,但无统计学意义。疗效观察,中毒症状及原发病体征好转消失时间IVIG组较An组明显缩短。本文还就IVIG对细胞免疫功能影响的可能机制进行了讨论。
Twelve neonates with severe infection were treated with IVIG and An. The therapeutic effects and adverse reactions were observed. The levels of T-lymphocyte subsets and interleukin-2 (IL-2) ) Produced changes in the level of observation of IVIG on cellular immune function. The results showed that the levels of CD_3 ~ +, CD_4 ~ +, CD_8 ~ + cells and IL-2 in children were significantly lower than those of normal neonate. After IVIG + An and single An treatment, the T cell subsets and IL-2 levels were significantly increased. Compared with An group, the number of CD_4 ~ + cells in IVIG group was significantly higher than that in An group and the level of IL-2 in An IV group was higher than that in An group. However, it was not statistically significant. Observation of curative effect, symptom of poisoning and disappearance of primary symptom improvement time were significantly shorter in IVIG group than in An group. This article also discusses the possible mechanisms by which IVIG affects cellular immune function.