Synthesis of c-Myb Protein(38-89)-NH_2 Using a Partially Protected Peptide Thioester

• 作 者: 张若蘅 徐筱杰 唐有祺 Hironobo Hojo Saburo Aimoto
• 机 构: Department of Chemistry,Peking University,Beijing 100871,PRC,Institute for Protein Research,Osaka Un
• 出 处: Science in China(Series B)
• 发表日期: 1994年08期
• 关键词: cysteine protected resin Peptide partially analogous dissolved monitored Cystein

The method of selective modification of eysteine SH group with 4-methylbenzylchloride isdeveloped,c-Myb protein (38-89)-NH_2 is synthesized by using a partially protected peptide thioester.The4-methylbenzyl (MeBzl) protecting group of cysteine in the building block is stable during the segment cou-pling.The method can be used in the chemical synthesis of some protein containing cysteine.

The method of selective modification of eysteine ​​SH group with 4-methylbenzylchloride isdeveloped, c-Myb protein (38-89) -NH_2 is synthesized by using a partially protected peptide thioester.The 4-methylbenzyl (MeBzl) protecting group of cysteine ​​in the building block is stable during the segment cou-pling. The method can be used in the chemical synthesis of some protein containing cysteine.