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目的观察番茄红素(lycopene from tomato,LP)对急性酒精中毒小鼠学习记忆障碍的预防作用。方法将30只小鼠随机分为生理盐水组(A组)、模型组(B组)、番茄红素组(C组),每组10只。A、B组给橄榄油,C组给番茄红素,1h后建立小鼠酒精中毒模型,24h后用跳台实验观察番茄红素单次给药对小鼠学习记忆的影响。结果番茄红素组可以延长急性酒精中毒小鼠跳台实验的潜伏期(p<0.05),减少错误次数(p<0.05)。结论番茄红素单次给药对急性酒精中毒小鼠的学习记忆障碍有预防作用。
Objective To observe the preventive effect of lycopene from tomato (LP) on learning and memory impairment in mice with acute alcoholism. Methods Thirty mice were randomly divided into normal saline group (group A), model group (group B) and lycopene group (group C), 10 in each group. A and B groups were given olive oil, and C group was given lycopene. A mouse model of alcoholism was established after 1 hour. After 24 hours, the effect of a single administration of lycopene on learning and memory of mice was observed by platform-descent experiments. Results The lycopene group could prolong the incubation period (p<0.05) and reduce the number of errors (p<0.05) in acute alcoholism mice. Conclusion The single administration of lycopene has a preventive effect on learning and memory impairment in mice with acute alcoholism.